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Research has shown that Rilmenidine proves to be effective for reducing symptoms of Huntington’s disease

Every day we bring to you the new developments happening in the world of the Huntington’s disease

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A drug which is getting tested for Huntington’s disease improves gait in mice

There is a new kind of Huntington’s disease drug which is right now undergoing clinical trials which

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Lower amount of ATF5 protein in cortex of HD patients

ATF5 protein causes the Huntington’s disease, any intervention which stops this protein from increasing

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CAG Repeats discovered by Francis Mojica

The CAG repeats that were discovered in Huntington’s disease gene were found out by Francis

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Mitochon gets patent for MP101 to be developed as a neural-cell-survival enhancing drug for Huntington’s disease

A new drug MP101 for the Huntington’s disease has received a patent from the U.S. Patent and

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Scientists unable to understand how Huntington’s disease is caused by immunity system

Scientists are in a dilemma as to how immunity causes Huntington’s disease.

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New gel found for facilitating 3D cell expansion in lower surface area

A significant development has happened which will lead to relief from the Huntington’s disease.

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Collaborative research getting used for discovering cure for Huntington’s disease

A new way of conducting research is happening in the field of Huntington’s disease. In this way

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Change in gut bacteria causes Huntington’s disease: Research

There are in-depth discoveries which are getting made into human bodies. One of the most

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Relatives of ALS patients more likely to get neuropsychiatric disorders: Research

New discoveries are happening in the field of Huntington’s disease. Now, there is a new finding

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HD can now be detected through saliva: Research

In an excellent new discovery, scientists have found a new way of finding the presence of Huntington’s

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Lambs used for finding a cure for Huntington’s disease: Research

There has been a great breakthrough in the field of the cure for the Huntington’s disease. As per a new

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Ganglioside GM1 known to cause reduction of HD symptoms

In a new research conducted by scientists, a new kind of cure has been revealed for the Huntington’s

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Httex1 levels go up in HD due to its structural changes

The scientists have now been able to diagnose the structural changes that happen in the Huntingtin

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Animal trials for HD to begin on a drug

There are soon to embark human trials for a drug which is going to be used for, treating the motor

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Gene therapy getting developed for treating Huntington’s disease

A great drug AMT-130 to stop the progression of Huntington’s disease is now under development

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Locana working on a RNA editing technique to cure HD

There is a new technique which is now getting developed for curing Huntington’s disease.

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Lesser patients required when using PFS instead of motor diagnosis as the basis for selection for trials

It has been problematic to find the right kind of patients for research on medicines for the Huntington’s

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CRISPR can be now be used precisely for neurological issues: Research

Now get more precise results through CRISPR for the treatment neurological issues like HD.

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CTE in brain to be detected via a blood test now: Boston University Research

Boston University has achieved success in finding how a blood test can be useful for detecting the

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ER-Mitochondria link important for Huntington’s disease | Research

Organelles are constituents of a cell which, responsible for executing distinct functions.

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Whether huntingtin lowering drugs are right or not?

A new research has now carefully evaluated the impact of the lowering of the huntingtin protein and

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Research – HD Patients should be admitted into hospitals at a later stage

A new research has indicated that the patients with Huntington’s disease should be admitted to the

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Discovery for antibodies for HD-causing proteins | TDP-43 | alpha-synuclein

The Swiss pharmaceutical company of AC Immune has detected two antibodies against the proteins.

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Huntington’s disease DNA mutation easy to be clocked now

Huntington’s disease has attracted the attention of researchers and scientists all over the world.

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Skin cells converted into motor neurons for curing Huntington’s disease

The scientists have found a new way through which they can derive neurons though skin cells transformation.

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New protein behind HD Discovered due to Professor Kwon Yong Tae

One of the fundamental news has been released about the Huntington’s disease. This news will change the perception on why Huntington’s disease is caused and how it can be cured. It’s established that the release of more protein in the Huntington’s disease causes it. As per this finding, the p62 … Continue reading New protein behind HD Discovered due to Professor Kwon Yong Tae

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New enzyme discovered behind gene changes in the Huntington’s disease

Huntington’s disease is debilitating with severe loss of cognitive and memory related capabilities. Now, scientists have found a new way to treat this disease which is through controlling the production of an enzyme named HDAC3 (histone deacetylase 3). This enzyme is known to modify the biochemical processes in the brain … Continue reading New enzyme discovered behind gene changes in the Huntington’s disease

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Research: HD affects hearing abilities also

  A new research has revealed that Huntington’s disease is a contributing cause of hearing disorder also. This conclusion was derived from a test for the finding of impaired hearing ability which was done on 17 patients with this disease, including 6 females and 11 males. These patients had already … Continue reading Research: HD affects hearing abilities also

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A motion detection machine invented for finding Chorea

  Three prodigious students Declan Goncalves, Hrishikesh Suresh and Zeqi Cui have developed a machine NeuroGate which can help in the timely diagnosis of Huntington’s disease by analyzing the gait of a likely patient. Since the major symptom of this disease is Chorea, which is uncontrollable body movements, this machine … Continue reading A motion detection machine invented for finding Chorea

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Scientists aiming at Huntingtin lowering to reduce chances of HD

Huntington’s Disease has been a cause of worry in the world. Now a new kind of drugs, are getting developed which can help in preventing this disease. Since this disease is caused by the increase in the size of the HD gene called HTT in the body, these drugs will … Continue reading Scientists aiming at Huntingtin lowering to reduce chances of HD

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PGD found to be sufficient for diagnosis of Huntington’s disease

PGD which stands for Preimplantation Genetic Diagnosis can be used to cure Huntington’s disease. It helps prevent pregnancies in those couples that have a risk of passing the Huntington’s disease since they carry the genes. This diagnosis conducts testing on oocytes and even embryos created through in-vitro fertilization. The test for … Continue reading PGD found to be sufficient for diagnosis of Huntington’s disease

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Scientists Can Now “Edit” Embryos

The MIT Technology Review reported Wednesday that, for the first time in the United States, scientists can now edit embryos.

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Gene Editing with CRISPR-Cas9

CRISPR-Cas9 is a gene editing technique used to make precise changes in DNA. Scientists have used this approach to attack the HD mutation in the mouse.

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Wave Life Sciences To Start Trials Of Two Therapies That Target Huntington’s Mutations

Two Phase 1b/2a clinical trials to investigate the safety and tolerability of its products WVE-120101 and WVE-120102 in Huntington’s disease patients.

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Potential HD Treatment Discovered by NUIG Researchers

Researchers have discovered encouraging early signs for a potential HD treatment. They targeted an enzyme called histone deacetylase 3 (HDAC3)

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New Data Network For HD Research

The first data network for research into HD has been created by an international team, now freely available to all scientists in this field.

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JAMA: HD Patients Can Safely Switch to Austedo Tablets

JAMA Neurology, published a research (ARC-HD) and showed that patients can easily switch from ingesting tetrabenazine to Austedo

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FDA Awarded New Chemical Entity (NCE) Exclusivity To Austedo

FDA recently awarded new chemical entity (NCE) exclusivity to Austedo™ (deutetrabenazine). NCE exclusivity benefits many innovators.

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A One-Step Triplet-Primed PCR And Melting Curve Assay

Molecular diagnosis of HD is currently performed by fluorescent repeat-flanking or triplet-primed PCR (TP-PCR) with capillary electrophoresis (CE).

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MSH3 Gene Mutations May Be Involved In HD Progression

Mutations of the MSH3 gene may be associated with the progression of the Huntington’s Disease according to a British study.

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New Huntington’s Disease Drug Austedo

The trial studied a new way of treating movements in HD. Now the Huntington’s Disease drug is approved for treatment in the US and is launched as Austedo.

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This New Gene Editing Technique Can Spot Mistakes Of CRISPR

Scientists have developed a tool that can test an entire genome against a CRISPR molecule to predict potential errors and interactions. This will allow doctors to ensure treatments are safer and more effective.

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Gene Therapy Vectors Come To Grips With Nervous System, Root And Branch

The vectors are customizable and could potentially be used as part of a gene therapy to treat neurodegenerative disorders

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Update Confirms HD ‘Gene Silencing’ Trial On Track

Ionis Pharmaceuticals launched the first ever trial of a Huntingtin drug – sometimes called a ‘gene silencing drug’.

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IONIS-HTT Rx Study in HD Patients Completes Enrollment

IONIS Pharmaceuticals announced the enrollment completion in its Phase 1/2a randomised, placebo-controlled, dose escalation study of IONIS-HTTRs in Huntington’s Disease (HD) patients.

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Inhibiting Enzyme Slows Huntington’s Progression in Mice and Lengthens Their Lives, Study Reports

Inhibiting the activity of an enzyme preserved the movement capabilities of mice with Huntington’s, slowed the progression of the disease and extended the animals’ lives, according to a study.

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CRISPR Reverses Huntington’s Disease in Mice

The potential of genome-editing techniques, such as CRISPR/Cas9, to alleviate disease burden has ignited the imagination for thousands of researchers looking for new therapeutic strategies. Scientists were very quickly able to show that this gene-altering technique could eliminate disease-causing mutations within a variety of tissues in vitro.

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Deep Brain Stimulation for the Treatment of Dystonia in HD

This research work is related to Deep Brain Stimulation for the Treatment of Dystonia in Huntington’s disease. Jessica Carl is a physician assistant and works at Rush University Medical Center in Chicago, particularly in the movement disorders section of neurological sciences.

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Pyk2 deficits contribute to memory problems in Huntington’s disease mouse model

Researchers from the Institute of Neurosciences of the UB and from IDIBAPS together with a team from the University Pierre and Marie Curie

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Blue-Ribbon Highlights: Rebuilding the Nigrostriatal Pathway

The 24 posters included among the blue-ribbon highlights at the International Congress of Huntington’s Disease and Movement Disorders here on June 8

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FDA Eyeing Patient-Reported Outcomes in Huntington’s Disease

As the FDA more seriously considers including patient-reported outcomes as part of its approval processes, a forum it held with Huntington’s disease care deeply about

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New Study Reveals A Potential HD Biomarker

What if a blood test could provide information about the status and course of HD? This is the premise of seeking HD biomarker; they may someday help guide treatment decisions and predict how symptoms will change

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Aripiprazole in the treatment of Huntington’s disease: a case series

Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder caused by the expansion of a CAG trinucleotide in the IT-15 gene on the short arm

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Finding Explains How Protein Aggregates Damage Neurons in Huntington’s Diseases

Researchers found that clumps of faulty protein involved in Alzheimer’s, Parkinson’s, and Huntington’s disease cause brain damage by invading and rupturing small

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Neuroprotective Pathway May Be Key to Understanding Huntington’s Progression

A team of researchers has discovered new insights into cell processes that have gone awry in Huntingon’s disease (HD) patients . The pathway under scrutiny is called NRF2

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Psychiatric Symptoms in Huntington Disease May Benefit From ECT

Electroconvulsive therapy (ECT) might be a reliable treatment for psychiatric symptoms in patients with Huntington disease (HD).

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Alzheimer’s, Parkinson’s, And Huntington’s Diseases Share Common Crucial Feature

Abnormal proteins found in Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease share a similar ability to cause damage. The study by senior author Edward Campbell, PhD, first author William Flavin

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Researchers Discover Why Defects Form In Blood Brain Barrier of Huntington’s Patients

Researchers have discovered why Huntington’s disease (HD) patients have defects in the blood-brain barrier that contribute to neurological disorder.

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Researchers Break Huntington’s Disease Stigma

The University’s Brain Repair and Intracranial Neurotherapeutics (BRAIN) Unit works to develop innovative therapies for Huntington’s Disease

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UC Health Helps Families Facing Huntington’s Disease Take a Significant Step Forward

Among the many movement disorders treated at UC Health, Huntington’s disease (HD) stands apart. Described as a “tragic inheritance,”

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Study Identifies New Biomarkers For Huntington’s Disease

P110 treatment corrected plasma mitochondrial DNA back to the levels seen in healthy mice. Mitochondrial DNA levels

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A Fat In Sheep Brains May Have The Ability To Treat Huntington Diseases

The fig overproduction of lipids in a lamb’s brain may be the key to treating degenerative brain diseases and brain injuries,

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Stem Cells Strike Back Against Huntington’s Disease

California Institute for Regenerative Medicine(CIRM) research team, headed by Dr. Vicki Wheelock and Dr. Jan Nolta at UC Davis,

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Study Finds Novel Insight into ‘Ballooning Cell Death’ in Huntington’s Patients

A new Japanese study confirms that a phenomenon called “ballooning cell death” (BCD) occurs in patients with Huntington’s disease.

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Usefulness of Animal Models to Study Stem Cell Therapy in Huntington’s Is Reviewed

A recent study reviewed the strengths and weaknesses of using animal studies to investigate the potential of stem cell therapy to treat Huntington’s disease. The mutated protein loses its normal activity, promoting neuronal loss and the development of clinical manifestations

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Levels of NFL Protein Could Help Track Huntington’s Progression, Study Suggests

Levels of a protein called neurofilament light (NFL) could be a valuable biomarker for tracking Huntington’s disease progression, according to a study.

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